Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.44 |
| ▸ | BCR | P11274 | 2/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.43 |
| ▸ | JAK2 | O60674 | 5/20 | 0.43 |
| ▸ | IKBKE | Q14164 | 5/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1667998 | 0.88 | ABL1 (0.46) | ABL1PDGFRBBCRPDGFRASRC | |
| SCHEMBL12521980 | 0.85 | ABL1 (0.43) | ABL1PDGFRBBCRPDGFRASRC | |
| SCHEMBL12801506 | 0.83 | IKBKE (0.56) | TBK1IKBKE | |
| SCHEMBL1667092 | 0.81 | JAK2 (0.50) | ABL1PDGFRBBCRPDGFRASRC | |
| SCHEMBL12521971 | 0.80 | JAK2 (0.49) | ABL1PDGFRBBCRPDGFRASRC | |
| SCHEMBL13279695 | 0.77 | TBK1 (0.50) | ABL1PDGFRBBCRPDGFRASRC | |
| SCHEMBL13279912 | 0.76 | TBK1 (0.52) | ABL1PDGFRBBCRPDGFRASRC | |
| SCHEMBL13279852 | 0.75 | TBK1 (0.49) | ABL1PDGFRBBCRPDGFRASRC | |
| SCHEMBL13279693 | 0.75 | TBK1 (0.51) | ABL1PDGFRBBCRPDGFRASRC | |
| SCHEMBL16132280 | 0.75 | TBK1 (0.47) | ABL1PDGFRBBCRPDGFRASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |