Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | AGXT | P21549 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31227766 | 0.86 | P2RX7 (0.37) | KDM4EKMT2AHTR2AHTR2CMEN1 | |
| SCHEMBL15779164 | 0.84 | KDM1A (0.40) | KDM4ESMN1; SMN2KMT2AMEN1P2RX7 | |
| SCHEMBL1285650 | 0.84 | IDO1 (0.40) | IDO1AGXTACHEKDM4ESMN1; SMN2 | |
| SCHEMBL15055515 | 0.84 | KMT2A (0.51) | KMT2AHTTHTR2AHTR2CP2RX7 | |
| SCHEMBL29751546 | 0.84 | P2RX7 (0.38) | SMN1; SMN2KMT2AGAAHTR2AHTR2C | |
| SCHEMBL24607728 | 0.84 | P2RX7 (0.38) | SMN1; SMN2KMT2AGAAHTR2AHTR2C | |
| SCHEMBL21915789 | 0.81 | HTR2A (0.39) | SMN1; SMN2KMT2AGAAHTR2AHTR2C | |
| SCHEMBL13724407 | 0.80 | MAPK1 (0.47) | SMN1; SMN2KMT2AGAAMAPK1HTT | |
| SCHEMBL30002930 | 0.78 | HTR2A (0.34) | KMT2AHTR2AHTR2CMEN1 | |
| SCHEMBL26530446 | 0.78 | IDO1 (0.46) | IDO1AGXTACHEKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011048409-A1 | CYCLIC AMINE DERIVATIVES HAVING BETA2 ADRENERGIC RECEPTOR AGONIST AND MUSCARINIC RECEPTOR ANTAGONIST ACTIVITY | ASTRAZENECA AB (SE) | 2011-04-28 | — | — | WO | disclosed |