Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 3/20 | 0.48 |
| ▸ | CDK8 | P49336 | 3/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | ZAP70 | P43403 | 5/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | IKBKB | O14920 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12521964 | 0.92 | CCNC (0.47) | CCNCCDK8GSK3BZAP70JAK2 | |
| SCHEMBL12801322 | 0.92 | GSK3B (0.49) | CCNCCDK8GSK3BJAK2CDK5 | |
| SCHEMBL12801341 | 0.91 | GSK3B (0.49) | CCNCCDK8GSK3BZAP70JAK2 | |
| SCHEMBL12275308 | 0.89 | CCNC (0.46) | CCNCCDK8GSK3BZAP70 | |
| SCHEMBL12801368 | 0.84 | GSK3B (0.43) | CCNCCDK8GSK3BZAP70JAK2 | |
| SCHEMBL12801676 | 0.83 | AURKB (0.55) | JAK2JAK3CDK5IKBKB | |
| SCHEMBL12801697 | 0.83 | ABL1 (0.50) | JAK2CDK5CDK2 | |
| SCHEMBL12801695 | 0.83 | IKBKB (0.52) | GSK3BJAK2JAK3CDK5IKBKB | |
| SCHEMBL12801280 | 0.82 | IKBKB (0.58) | ZAP70JAK2JAK3CDK5IKBKB | |
| SCHEMBL12801123 | 0.82 | PDPK1 (0.49) | ZAP70JAK2JAK3CDK5SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |