Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 12/20 | 0.45 |
| ▸ | JAK2 | O60674 | 4/20 | 0.43 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.43 |
| ▸ | NEK3 | P51956 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | NEK5 | Q6P3R8 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801379 | 0.90 | CDC7 (0.51) | TBK1JAK2MYLK4STK17ANEK3 | |
| SCHEMBL1667478 | 0.90 | TBK1 (0.57) | TBK1JAK2 | |
| SCHEMBL12800894 | 0.89 | CDC7 (0.46) | TBK1JAK2MYLK4STK17ANEK3 | |
| SCHEMBL12801598 | 0.88 | TBK1 (0.48) | TBK1JAK2MYLK4STK17ANEK3 | |
| SCHEMBL12801665 | 0.88 | TBK1 (0.48) | TBK1JAK2MYLK4STK17ANEK3 | |
| SCHEMBL12801538 | 0.85 | TBK1 (0.53) | TBK1JAK2MYLK4STK17ANEK3 | |
| SCHEMBL12801252 | 0.83 | JAK2 (0.59) | TBK1JAK2JAK3 | |
| SCHEMBL12801663 | 0.83 | JAK2 (0.59) | TBK1JAK2JAK3 | |
| SCHEMBL12801316 | 0.83 | JAK2 (0.45) | TBK1JAK2JAK3CDK2CCNA2 | |
| SCHEMBL12800954 | 0.82 | JAK2 (0.52) | TBK1JAK2STK17AJAK3CDK19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |