Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 9/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.45 |
| ▸ | PRKCG | P05129 | 2/20 | 0.45 |
| ▸ | PRKCB | P05771 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | PRKCA | P17252 | 2/20 | 0.45 |
| ▸ | PRKCH | P24723 | 2/20 | 0.45 |
| ▸ | PRKCI | P41743 | 2/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.45 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.45 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12274144 | 0.90 | TBK1 (0.55) | ZAP70JAK2PDGFRBPDGFRAACVR1 | |
| SCHEMBL1667253 | 0.81 | TBK1 (0.54) | ZAP70JAK2PRKD3PRKCGPRKCB | |
| SCHEMBL12801104 | 0.80 | JAK2 (0.47) | ZAP70JAK2PRKD3PRKCGPRKCB | |
| SCHEMBL1669928 | 0.79 | TBK1 (0.52) | ZAP70JAK2PRKD3PRKCGPRKCB | |
| SCHEMBL4379779 | 0.79 | ZAP70 (0.60) | ZAP70JAK2PDGFRBPDGFRAACVR1 | |
| SCHEMBL4558021 | 0.78 | ZAP70 (0.59) | ZAP70JAK2PDGFRBPDGFRAACVR1 | |
| SCHEMBL12275103 | 0.78 | TBK1 (0.49) | ZAP70JAK2PRKD3PRKCGPRKCB | |
| SCHEMBL4385351 | 0.77 | ZAP70 (0.57) | ZAP70JAK2PDGFRBPDGFRAACVR1 | |
| SCHEMBL12274385 | 0.76 | TBK1 (0.56) | ZAP70JAK2PRKD3PRKCGPRKCB | |
| SCHEMBL12800946 | 0.75 | JAK2 (0.65) | JAK2PDGFRAACVR1PRKD3LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |