Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 19/20 | 0.67 |
| ▸ | JAK2 | O60674 | 5/20 | 0.67 |
| ▸ | IKBKE | Q14164 | 14/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29772697 | 0.93 | TBK1 (0.76) | TBK1JAK2IKBKE | |
| SCHEMBL1667556 | 0.93 | TBK1 (0.76) | TBK1JAK2IKBKE | |
| SCHEMBL1667172 | 0.92 | TBK1 (0.69) | TBK1JAK2IKBKE | |
| SCHEMBL1667100 | 0.90 | TBK1 (0.71) | TBK1JAK2IKBKE | |
| SCHEMBL1667187 | 0.90 | TBK1 (0.64) | TBK1JAK2IKBKE | |
| SCHEMBL12274012 | 0.90 | TBK1 (0.64) | TBK1JAK2IKBKE | |
| SCHEMBL12522280 | 0.90 | TBK1 (0.64) | TBK1JAK2IKBKE | |
| SCHEMBL1667659 | 0.89 | TBK1 (0.70) | TBK1JAK2IKBKE | |
| SCHEMBL12275053 | 0.89 | TBK1 (0.63) | TBK1JAK2IKBKE | |
| SCHEMBL1667417 | 0.89 | TBK1 (0.63) | TBK1JAK2IKBKE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |