Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.56 |
| ▸ | IKBKE | Q14164 | 14/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 14/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12801081 | 0.93 | JAK2 (0.56) | JAK2IKBKETBK1JAK3CDK1 | |
| SCHEMBL12801684 | 0.91 | JAK2 (0.49) | JAK2IKBKETBK1JAK3 | |
| SCHEMBL12801232 | 0.89 | JAK2 (0.61) | JAK2IKBKETBK1JAK3SMG1 | |
| SCHEMBL12801124 | 0.89 | JAK2 (0.54) | JAK2IKBKETBK1JAK3CDK1 | |
| SCHEMBL12801087 | 0.89 | JAK2 (0.54) | JAK2IKBKETBK1JAK3 | |
| SCHEMBL12801662 | 0.88 | JAK2 (0.68) | JAK2IKBKETBK1JAK3 | |
| SCHEMBL1667995 | 0.88 | TBK1 (0.66) | JAK2IKBKETBK1 | |
| SCHEMBL12801117 | 0.88 | JAK2 (0.53) | JAK2IKBKETBK1JAK3SMG1 | |
| SCHEMBL12801131 | 0.87 | IKBKE (0.51) | JAK2IKBKETBK1 | |
| SCHEMBL12801095 | 0.87 | JAK2 (0.56) | JAK2IKBKETBK1JAK3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011046970-A1 | AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBKL AND/OR IKK EPSILON | MYREXIS, INC. (US) | 2011-04-21 | — | — | WO | disclosed |