Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rizatriptan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D known ✓ | P28221 | 5/20 | 1.00 |
| ▸ | HTR1B known ✓ | P28222 | 5/20 | 1.00 |
| ▸ | HTR1A | P08908 | 12/20 | 1.00 |
| ▸ | HTR2C | P28335 | 9/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | HTR2A | P28223 | 1/20 | 1.00 |
| ▸ | HRH1 | P35367 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 1/20 | 1.00 |
| ▸ | HTR5A | P47898 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rizatriptan SCHEMBL26662 | 1.00 | HTR1A (1.00) | HTR1AHTR2CHTR1DHTR1BADRA2C | |
| Rizatriptan SCHEMBL29407208 | 1.00 | HTR1A (1.00) | HTR1AHTR2CHTR1DHTR1BADRA2C | |
| Rizatriptan SCHEMBL28815652 | 0.99 | HTR1A (0.98) | HTR1AHTR2CHTR1DHTR1BADRA2C | |
| Rizatriptan SCHEMBL28840728 | 0.94 | HTR1A (0.88) | HTR1AHTR2CHTR1DHTR1BADRA2C | |
| Rizatriptan SCHEMBL2231061 | 0.94 | HTR1A (0.88) | HTR1AHTR2CHTR1DHTR1BADRA2C | |
| Rizatriptan SCHEMBL8809846 | 0.93 | HTR1A (0.86) | HTR1AHTR2CHTR1DHTR1BADRA2C | |
| Rizatriptan SCHEMBL1650947 | 0.93 | HTR1A (0.86) | HTR1AHTR2CHTR1DHTR1BADRA2C | |
| Rizatriptan SCHEMBL8809854 | 0.93 | HTR1A (0.86) | HTR1AHTR2CHTR1DHTR1BADRA2C | |
| Rizatriptan SCHEMBL3462253 | 0.92 | HTR1A (0.85) | HTR1AHTR2CHTR1DHTR1BADRA2C | |
| Rizatriptan SCHEMBL2326617 | 0.91 | HTR1A (0.83) | HTR1AHTR2CHTR1DHTR1BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2490669-B1 | TRIPTANS FOR THE TREATMENT OF PSORIASIS | FORTUDERM LTD (IL) | 2017-01-11 | — | — | EP | disclosed |
| US-20140155443-A1 | COMPOSITIONS AND METHODS OF TREATMENT FOR PSORIASIS | DASCALU AVI (IL) | 2014-06-05 | — | — | US | disclosed |
| US-8680134-B2 | Triptans for the treatment of psoriasis | DASCALU AVI (IL) | 2014-03-25 | — | — | US | disclosed |
| US-20120252863-A1 | TRIPTANS FOR THE TREATMENT OF PSORIASIS | DASCALU AVI (IL) | 2012-10-04 | — | — | US | disclosed |