Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 19/20 | 1.00 |
| ▸ | DPP8 | Q6V1X1 | 11/20 | 1.00 |
| ▸ | DPP9 | Q86TI2 | 6/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12807245 | 0.86 | DPP4 (1.00) | DPP4DPP8DPP9 | |
| SCHEMBL12807246 | 0.83 | DPP4 (1.00) | DPP4DPP8DPP9 | |
| SCHEMBL12807244 | 0.82 | DPP4 (1.00) | DPP4DPP8DPP9 | |
| SCHEMBL8260480 | 0.77 | DPP4 (0.78) | DPP4DPP8DPP9 | |
| SCHEMBL12807365 | 0.73 | DPP4 (0.58) | DPP4DPP8DPP9 | |
| SCHEMBL4467599 | 0.72 | DPP4 (0.59) | DPP4DPP8 | |
| SCHEMBL1407569 | 0.70 | DPP4 (0.78) | DPP4DPP8DPP9 | |
| SCHEMBL1408219 | 0.70 | DPP4 (0.78) | DPP4DPP8DPP9 | |
| SCHEMBL8259038 | 0.68 | DPP4 (0.75) | DPP4DPP8DPP9 | |
| SCHEMBL1408213 | 0.68 | DPP4 (0.82) | DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2308847-B1 | Substituted pyridines as inhibitors of dipeptidyl peptidase IV and their application for the treatment of diabetes and related diseases | EMC MICROCOLLECTIONS GMBH (DE) | 2014-04-02 | — | — | EP | disclosed |
| EP-2308847-A1 | Substituted pyridines as inhibitors of dipeptidyl peptidase IV and their application for the treatment of diabetes and related diseases | EMC microcollections GmbH (DE) | 2011-04-13 | — | — | EP | disclosed |