Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 17/20 | 1.00 |
| ▸ | DPP8 | Q6V1X1 | 13/20 | 1.00 |
| ▸ | DPP9 | Q86TI2 | 8/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12807243 | 0.83 | DPP4 (1.00) | DPP4DPP8DPP9 | |
| SCHEMBL8254459 | 0.81 | DPP4 (1.00) | DPP4DPP8DPP9 | |
| SCHEMBL8252761 | 0.80 | DPP4 (0.98) | DPP4DPP8DPP9 | |
| SCHEMBL12807245 | 0.80 | DPP4 (1.00) | DPP4DPP8DPP9 | |
| SCHEMBL8259030 | 0.79 | DPP4 (0.96) | DPP4DPP8DPP9 | |
| SCHEMBL12807262 | 0.78 | DPP4 (1.00) | DPP4DPP8DPP9NPC1RAB9A | |
| SCHEMBL12807244 | 0.75 | DPP4 (1.00) | DPP4DPP8DPP9 | |
| SCHEMBL8252584 | 0.74 | DPP4 (0.86) | DPP4DPP8DPP9 | |
| SCHEMBL8257315 | 0.74 | DPP4 (0.86) | DPP4DPP8DPP9 | |
| SCHEMBL8259034 | 0.73 | DPP4 (0.85) | DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2308847-B1 | Substituted pyridines as inhibitors of dipeptidyl peptidase IV and their application for the treatment of diabetes and related diseases | EMC MICROCOLLECTIONS GMBH (DE) | 2014-04-02 | — | — | EP | disclosed |
| EP-2308847-A1 | Substituted pyridines as inhibitors of dipeptidyl peptidase IV and their application for the treatment of diabetes and related diseases | EMC microcollections GmbH (DE) | 2011-04-13 | — | — | EP | disclosed |