Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 8/20 | 1.00 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.64 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12807363 | 0.82 | DPP4 (0.69) | DPP4DPP8GRM2 | |
| SCHEMBL12807246 | 0.78 | DPP4 (1.00) | DPP4DPP8NPC1RAB9ADPP9 | |
| SCHEMBL12807260 | 0.76 | DPP4 (1.00) | DPP4DPP8NPC1RAB9ADPP9 | |
| SCHEMBL12807264 | 0.68 | DPP4 (0.55) | DPP4DPP8NPC1RAB9ADPP9 | |
| SCHEMBL1678228 | 0.68 | CFTR (0.52) | DPP4DPP8GRM2MAPTHPGD | |
| SCHEMBL14919554 | 0.67 | GRM2 (1.00) | GRM2 | |
| SCHEMBL14933149 | 0.66 | GRM2 (1.00) | GRM2 | |
| SCHEMBL16168960 | 0.66 | GRM2 (0.81) | DPP4GRM2NPC1RAB9AHPGD | |
| SCHEMBL16599357 | 0.65 | NPC1 (0.49) | DPP4GRM2NPC1RAB9ATP53 | |
| SCHEMBL12807261 | 0.64 | DPP4 (1.00) | DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2308847-B1 | Substituted pyridines as inhibitors of dipeptidyl peptidase IV and their application for the treatment of diabetes and related diseases | EMC MICROCOLLECTIONS GMBH (DE) | 2014-04-02 | — | — | EP | disclosed |
| EP-2308847-A1 | Substituted pyridines as inhibitors of dipeptidyl peptidase IV and their application for the treatment of diabetes and related diseases | EMC microcollections GmbH (DE) | 2011-04-13 | — | — | EP | disclosed |