Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 19/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1403523 | 1.00 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL1403530 | 1.00 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL1403525 | 1.00 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL1403528 | 1.00 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL13108700 | 1.00 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL1402821 | 0.92 | HSD11B1 (0.85) | HSD11B1 | |
| SCHEMBL1402825 | 0.92 | HSD11B1 (0.85) | HSD11B1 | |
| SCHEMBL1402826 | 0.92 | HSD11B1 (0.85) | HSD11B1 | |
| SCHEMBL1402823 | 0.92 | HSD11B1 (0.85) | HSD11B1 | |
| SCHEMBL14135395 | 0.92 | HSD11B1 (0.84) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2292228-A1 | Pyrazole derivatives as 11-beta-HSD1 inhibitors | AstraZeneca AB (Publ) (SE) | 2011-03-09 | — | — | EP | disclosed |
| WO-2008099145-A1 | PYRAZOLE DERIVATIVES AS 11-BETA-HSD1 INHIBITORS | ASTRAZENECA AB (SE) | 2008-08-21 | — | — | WO | disclosed |