Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 13/20 | 0.69 |
| ▸ | DPP8 | Q6V1X1 | 8/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | DPP9 | Q86TI2 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8256363 | 0.81 | DPP4 (1.00) | DPP4DPP8CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL8258286 | 0.79 | DPP4 (0.70) | DPP4DPP8CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL8256348 | 0.76 | DPP4 (1.00) | DPP4DPP8CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL1407793 | 0.72 | DPP4 (1.00) | DPP4DPP8CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL8258283 | 0.72 | DPP4 (0.67) | DPP4DPP8CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL8256222 | 0.72 | DPP4 (0.67) | DPP4DPP8CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL8256321 | 0.72 | DPP4 (1.00) | DPP4DPP8CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL8256325 | 0.72 | DPP4 (1.00) | DPP4DPP8CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL461032 | 0.71 | NPC1 (0.57) | DPP4DPP8CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL8260568 | 0.67 | DPP4 (1.00) | DPP4DPP8CYP2C19CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836206-B1 | AZOLOPYRIMIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS | BRISTOL MYERS SQUIBB CO (US) | 2011-03-09 | — | — | EP | disclosed |