Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 13/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | DPP8 | Q6V1X1 | 6/20 | 0.65 |
| ▸ | DPP9 | Q86TI2 | 5/20 | 0.65 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8258283 | 0.82 | DPP4 (0.67) | DPP4CYP3A4CYP2C19CYP2C9DPP8 | |
| SCHEMBL1407793 | 0.82 | DPP4 (1.00) | DPP4CYP3A4CYP2C19CYP2C9DPP8 | |
| SCHEMBL8256222 | 0.82 | DPP4 (0.67) | DPP4CYP3A4CYP2C19CYP2C9DPP8 | |
| SCHEMBL8256321 | 0.79 | DPP4 (1.00) | DPP4CYP3A4CYP2C19CYP2C9DPP8 | |
| SCHEMBL12809486 | 0.79 | DPP4 (0.69) | DPP4CYP3A4CYP2C19CYP2C9DPP8 | |
| SCHEMBL8258593 | 0.79 | DPP4 (0.70) | DPP4CYP3A4CYP2C19DPP8DPP9 | |
| SCHEMBL8256363 | 0.78 | DPP4 (1.00) | DPP4CYP3A4CYP2C19CYP2C9DPP8 | |
| SCHEMBL8254534 | 0.76 | DPP4 (1.00) | DPP4CYP3A4CYP2C19CYP2C9DPP8 | |
| SCHEMBL8256348 | 0.75 | DPP4 (1.00) | DPP4CYP3A4CYP2C19CYP2C9DPP8 | |
| SCHEMBL8257973 | 0.74 | DPP4 (1.00) | DPP4CYP3A4CYP2C19CYP2C9DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836206-B1 | AZOLOPYRIMIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS | BRISTOL MYERS SQUIBB CO (US) | 2011-03-09 | — | — | EP | disclosed |
| US-7635699-B2 | Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-22 | — | — | US | disclosed |
| US-7635699-B2 | Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-22 | — | — | US | disclosed |
| WO-2006071752-A1 | AZOLOPYRIMIDINE-BASED INHIBITORS OF DIPEPTIDYL PEPTIDASE IV AND METHODS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-07-06 | — | — | WO | disclosed |