Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | FBP1 | P09467 | 7/20 | 0.42 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1706770 | 1.00 | KMT2A (0.53) | KMT2AMEN1ACHEALDH1A1FBP1 | |
| SCHEMBL12808 | 0.82 | KMT2A (0.57) | KMT2AMEN1ACHEALDH1A1FBP1 | |
| SCHEMBL24517491 | 0.81 | KMT2A (0.52) | KMT2AMEN1ACHEALDH1A1FBP1 | |
| SCHEMBL1299476 | 0.80 | KMT2A (0.55) | KMT2AMEN1ACHEALDH1A1FBP1 | |
| SCHEMBL822302 | 0.79 | KMT2A (0.59) | KMT2AMEN1ACHEALDH1A1FBP1 | |
| SCHEMBL29468572 | 0.79 | KMT2A (0.59) | KMT2AMEN1ACHEALDH1A1FBP1 | |
| SCHEMBL1706810 | 0.79 | KMT2A (0.55) | KMT2AMEN1ACHEALDH1A1FBP1 | |
| SCHEMBL18445871 | 0.78 | HSD17B1 (0.49) | ACHEALDH1A1MMP2LMNA | |
| SCHEMBL8264434 | 0.78 | KMT2A (0.53) | KMT2AMEN1ACHEALDH1A1FBP1 | |
| SCHEMBL18402627 | 0.78 | KMT2A (0.49) | KMT2AMEN1ACHEALDH1A1FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046758-B1 | SUBSTITUTED SULPHOXIMINES AS TIE2 INHIBITORS AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | BAYER SCHERING PHARMA AG (DE) | 2011-03-16 | — | — | EP | disclosed |