Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK6 | Q00534 | 3/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.48 |
| ▸ | MTOR | P42345 | 6/20 | 0.48 |
| ▸ | PRKDC | P78527 | 1/20 | 0.48 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | SORD | Q00796 | 2/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12812038 | 0.89 | PIK3CA (0.46) | CDK6PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL12811942 | 0.84 | PIK3CA (0.54) | CDK6PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1443477 | 0.83 | PIK3CA (0.52) | CDK6PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL3091537 | 0.82 | PIK3CA (0.55) | CDK6PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL12811940 | 0.82 | PIK3CA (0.47) | CDK6PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL12812019 | 0.81 | PIK3CA (0.52) | CDK6PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1441659 | 0.81 | PIK3CA (0.52) | CDK6PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1442664 | 0.81 | PIK3CD (0.49) | CDK6PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1441788 | 0.81 | PIK3CA (0.63) | CDK6PIK3CAPIK3CBPIK3CGPIK3CD | |
| SCHEMBL1442463 | 0.80 | CDK6 (0.50) | CDK6PIK3CAPIK3CBPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011026579-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-03-10 | — | — | WO | disclosed |