Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.46 |
| ▸ | SORD | Q00796 | 2/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.41 |
| ▸ | MTOR | P42345 | 4/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TNF | P01375 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12811782 | 0.89 | CDK6 (0.48) | PIK3CASORDPIK3CBMTORPIK3CG | |
| SCHEMBL12811955 | 0.85 | GAK (0.42) | PIK3CASORDPIK3CBMTORPIK3CG | |
| SCHEMBL1442748 | 0.83 | PIK3CA (0.53) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL1442186 | 0.82 | PIK3CA (0.50) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL12812033 | 0.80 | PIK3CA (0.50) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL1442475 | 0.80 | PIK3CA (0.50) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL1442437 | 0.80 | PIK3CA (0.47) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL1442090 | 0.80 | PDGFRB (0.51) | PIK3CAPIK3CBPIK3CGPIK3CDLMNA | |
| SCHEMBL1442237 | 0.80 | PIK3CA (0.61) | PIK3CAPIK3CBMTORPIK3CGPIK3CD | |
| SCHEMBL13276622 | 0.79 | PIK3CA (0.48) | PIK3CASORDPIK3CBMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011026579-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-03-10 | — | — | WO | disclosed |