Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.44 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1442584 | 0.84 | HPGD (0.58) | HPGDPIK3CAHCAR2MKNK1MKNK2 | |
| SCHEMBL27865711 | 0.83 | HPGD (0.43) | HPGDPIK3CACDC7CDK9ROCK2 | |
| SCHEMBL28799905 | 0.82 | CDC7 (0.43) | HPGDPIK3CACDC7CDK9ROCK2 | |
| SCHEMBL27865694 | 0.81 | HPGD (0.41) | HPGDPIK3CACDC7CDK9ROCK2 | |
| SCHEMBL1443528 | 0.81 | HPGD (0.50) | HPGDPIK3CACDK9HCAR2 | |
| SCHEMBL28799885 | 0.79 | HPGD (0.40) | HPGDPIK3CACDC7CDK9ROCK2 | |
| SCHEMBL1444121 | 0.77 | PIK3CA (0.48) | HPGDPIK3CAHCAR2PIK3CBMTOR | |
| SCHEMBL1443341 | 0.77 | PIK3CA (0.47) | HPGDPIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL1444076 | 0.76 | HPGD (0.59) | HPGD | |
| SCHEMBL10179643 | 0.76 | HPGD (0.59) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011026579-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-03-10 | — | — | WO | disclosed |