Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.56 |
| ▸ | MTOR | P42345 | 6/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.56 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.47 |
| ▸ | FYN | P06241 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1443297 | 0.97 | PIK3CA (0.53) | PIK3CAPIK3CGPIK3CBMTORPIK3CD | |
| SCHEMBL12812432 | 0.91 | MAP4K4 (0.50) | PIK3CAPIK3CGPIK3CBMTORPIK3CD | |
| SCHEMBL1442919 | 0.90 | PIK3CA (0.48) | PIK3CAPIK3CGPIK3CBMTORPIK3CD | |
| SCHEMBL1442553 | 0.85 | ATR (0.50) | PIK3CAPIK3CGPIK3CBMTORPIK3CD | |
| SCHEMBL10180104 | 0.84 | HDAC1 (0.51) | MAP4K4 | |
| SCHEMBL13276742 | 0.83 | HSD17B10 (0.51) | PIK3CAPIK3CGPIK3CBMTORPIK3CD | |
| SCHEMBL1443793 | 0.83 | STK17A (0.48) | PIK3CAPIK3CGPIK3CBMTORPIK3CD | |
| SCHEMBL12812018 | 0.83 | MAPK14 (0.61) | PIK3CAPIK3CGPIK3CBMTORPIK3CD | |
| SCHEMBL12811768 | 0.82 | PRKDC (0.49) | PIK3CAPIK3CGPIK3CBMTORPIK3CD | |
| SCHEMBL1442554 | 0.82 | LRRK2 (0.47) | PIK3CAPIK3CGPIK3CBMTORPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9340528-B2 | Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-05-17 | — | — | US | claimed |
| US-20120263708-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-10-18 | — | — | US | claimed |
| CN-102596932-A | Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors | BAYER SCHERING PHARMA AG | 2012-07-18 | — | — | CN | claimed |
| US-9340528-B2 | Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-05-17 | — | — | US | disclosed |
| US-9340528-B2 | Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2016-05-17 | — | — | US | disclosed |
| US-20120263708-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-10-18 | — | — | US | disclosed |
| US-20120263708-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-10-18 | — | — | US | disclosed |
| WO-2011026579-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120263708-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | ABL1, TYK2, JAK2 | PIK3CA 181/4885PIK3CG 412/4885PIK3CB 404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.