Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.48 |
| ▸ | MTOR | P42345 | 6/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.48 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | STAMBP | O95630 | 1/20 | 0.42 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1443297 | 0.93 | PIK3CA (0.53) | PIK3CAPIK3CGPIK3CBMTORPIK3CD | |
| SCHEMBL12812436 | 0.90 | PIK3CA (0.56) | PIK3CAPIK3CGPIK3CBMTORPIK3CD | |
| SCHEMBL12812432 | 0.89 | MAP4K4 (0.50) | PIK3CAPIK3CGPIK3CBMTORPIK3CD | |
| SCHEMBL1442553 | 0.77 | ATR (0.50) | PIK3CAPIK3CGPIK3CBMTORPIK3CD | |
| SCHEMBL1442602 | 0.77 | PIK3CA (0.48) | PIK3CAPIK3CGPIK3CBMTORPIK3CD | |
| SCHEMBL1443793 | 0.76 | STK17A (0.48) | PIK3CAPIK3CGPIK3CBMTORPIK3CD | |
| SCHEMBL10180104 | 0.76 | HDAC1 (0.51) | PSMD14STAMBPCOPS5MAP4K4JAK2 | |
| SCHEMBL12812408 | 0.76 | PIM1 (0.51) | PIK3CAPIK3CGPIK3CBMTORPIK3CD | |
| SCHEMBL13276742 | 0.75 | HSD17B10 (0.51) | PIK3CAPIK3CGPIK3CBMTORPIK3CD | |
| SCHEMBL1442119 | 0.75 | CDK8 (0.47) | PIK3CAPIK3CGMAPTSMN1; SMN2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2473498-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | Bayer Pharma Aktiengesellschaft (DE) | 2012-07-11 | — | — | EP | claimed |
| WO-2011026579-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-03-10 | — | — | WO | claimed |