Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 4/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.45 |
| ▸ | MTOR | P42345 | 4/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.45 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1442429 | 0.86 | GBA1 (0.61) | GBA1PIK3CAMTORPIK3CDPIK3CG | |
| SCHEMBL1442827 | 0.84 | GBA1 (0.61) | GBA1PIK3CAMTORPIK3CDPIK3CG | |
| SCHEMBL1442936 | 0.83 | GBA1 (0.63) | GBA1PIK3CAGLAHPGDKDM4E | |
| SCHEMBL1442442 | 0.81 | MTOR (0.53) | GBA1PIK3CAMTORPIK3CDPIK3CG | |
| SCHEMBL1442411 | 0.81 | GAA (0.52) | GBA1PIK3CAMTORPIK3CDPIK3CG | |
| SCHEMBL13276289 | 0.80 | MTOR (0.60) | PIK3CAMTORPIK3CDPIK3CGPIK3CB | |
| SCHEMBL1443457 | 0.80 | SHMT2 (0.52) | GBA1PIK3CAMTORPIK3CDPIK3CG | |
| SCHEMBL12812451 | 0.79 | GBA1 (0.48) | GBA1PIK3CAMTORPIK3CDPIK3CG | |
| SCHEMBL1442884 | 0.78 | KDM4E (0.53) | GBA1PIK3CAMTORPIK3CGKDM4E | |
| SCHEMBL1444071 | 0.78 | PIK3CA (0.67) | PIK3CAMTORPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011026579-A1 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-03-10 | — | — | WO | disclosed |