SHMT2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL627524	0.43	4/20
SCHEMBL573199	0.51	3/20
SCHEMBL628055	0.51	3/20
SCHEMBL629227	0.48	3/20
SCHEMBL628071	0.44	3/20
SCHEMBL485363	0.43	3/20
SCHEMBL628748	0.42	3/20
SCHEMBL282683	0.41	3/20
SCHEMBL598915	0.56	2/20
SCHEMBL599133	0.50	2/20
SCHEMBL491416	0.49	2/20
SCHEMBL418577	0.45	2/20
SCHEMBL485245	0.42	2/20
SCHEMBL485633	0.42	2/20
SCHEMBL977443	0.42	2/20
SCHEMBL418556	0.41	2/20
SCHEMBL64843	0.41	2/20
SCHEMBL485467	0.38	2/20
SCHEMBL625971	0.37	2/20
SCHEMBL878217	0.36	2/20

Clinical trials — most relevant to SHMT2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Fat, Inflammation and Insulin Resistance	PHASE4	COMPLETED
Effect of Pioglitazone Administered to Patients With Friedreich's Ataxia: Proof of Concept	PHASE3	COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
A Placebo-controlled Trial of Folinic Acid in Children With ASD	PHASE2	RECRUITING
Pioglitazone Therapy Targeting Fatigue in Breast Cancer	PHASE2	RECRUITING
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome	PHASE1/PHASE2	COMPLETED
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients	PHASE2	COMPLETED
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD	nan	NOT_YET_RECRUITING
Diabetic Cardiomyopathy and Heart Failure	nan	WITHDRAWN
Treating Oxidative Stress and the Metabolic Pathology of Autism	nan	COMPLETED
Impact Of Choline in Patients With NAFLD	nan	UNKNOWN
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer	nan	UNKNOWN
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Transgenerational Metabolic-Immune Biomarkers of Neurological and Neurodevelopmental Disorders	nan	RECRUITING
Proof of Concept Creatine Supplementation for Homocystinuria Study	nan	ACTIVE_NOT_RECRUITING
Mitochondrial Methylation in Type 2 Diabetes	nan	COMPLETED
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases	nan	COMPLETED
Mitochondrial Health and Hemodynamic Instability Related to Renal Replacement Therapy in Critically Ill Patients	nan	UNKNOWN
The Crosstalk Between the Epigenome and Mitochondria in SCI	nan	NOT_YET_RECRUITING
Mitochondrial Dysfunction in Diabetes	nan	COMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy	nan	COMPLETED
Exercise Resistance in Type 2 Diabetes	nan	ACTIVE_NOT_RECRUITING
The PRE-OP ENERGY Trial	nan	UNKNOWN
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Combined Effects of Statins and Exercise on Training Sensitive Health Markers	nan	COMPLETED
Immune Responses With Reduxium	nan	COMPLETED
Ataxia-telangiectasia: Treating Mitochondrial Dysfunction With Nicotinamide Riboside	nan	UNKNOWN
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients.	nan	COMPLETED
Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide	nan	RECRUITING
The Natural History of Mitochondrial Diseases	nan	RECRUITING

Related proteins — ESM-2 sequence neighbours (a SHMT2 binder may also engage these)

Protein	Name	Similarity
Q9CZN7	—	1.000	Q9CZN7 →
P14519	—	1.000	P14519 →
Q3SZ20	—	1.000	Q3SZ20 →
P50431	—	1.000	P50431 →
Q5RFK5	—	1.000	Q5RFK5 →
B0B804	—	1.000	B0B804 →
Q94C74	—	0.999	Q94C74 →
Q54EW1	—	0.999	Q54EW1 →
Q9SZJ5	—	0.999	Q9SZJ5 →
B0BC69	—	0.998	B0BC69 →
P50432	—	0.998	P50432 →
O13972	—	0.998	O13972 →
Q3KLR8	—	0.998	Q3KLR8 →
P34898	—	0.998	P34898 →
P07511	—	0.997	P07511 →
Q758F0	—	0.996	Q758F0 →
P49358	—	0.996	P49358 →
Q9PJW0	—	0.996	Q9PJW0 →
Q5E9P9	—	0.995	Q5E9P9 →
P49357	—	0.995	P49357 →
A8M1D3	—	0.994	A8M1D3 →
Q4WXF4	—	0.994	Q4WXF4 →
P34899	—	0.994	P34899 →
O84439	—	0.993	O84439 →
Q60V73	—	0.993	Q60V73 →
P35623	—	0.993	P35623 →
Q6FQ44	—	0.993	Q6FQ44 →
P37292	—	0.993	P37292 →
P50433	—	0.992	P50433 →
Q9SVM4	—	0.992	Q9SVM4 →