Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MTOR | P42345 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | GMNN | O75496 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | HBB | P68871 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.45 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.45 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | PYGM | P11217 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 6-Chloroguanine SCHEMBL12813167 | 0.86 | LMNA (0.49) | LMNAMTORTP53GMNNALDH1A1 | |
| SCHEMBL5697581 | 0.83 | LMNA (0.62) | LMNAMTORTP53GMNNALDH1A1 | |
| SCHEMBL5953706 | 0.83 | LMNA (0.62) | LMNAMTORTP53GMNNALDH1A1 | |
| SCHEMBL14929291 | 0.83 | LMNA (0.62) | LMNAMTORTP53GMNNALDH1A1 | |
| SCHEMBL14441083 | 0.83 | LMNA (0.62) | LMNAMTORTP53GMNNALDH1A1 | |
| SCHEMBL2579580 | 0.83 | LMNA (0.62) | LMNAMTORTP53GMNNALDH1A1 | |
| SCHEMBL41572 | 0.83 | LMNA (0.62) | LMNAMTORTP53GMNNALDH1A1 | |
| SCHEMBL18512948 | 0.83 | LMNA (0.62) | LMNAMTORTP53GMNNALDH1A1 | |
| SCHEMBL5953287 | 0.83 | LMNA (0.62) | LMNAMTORTP53GMNNALDH1A1 | |
| SCHEMBL6297856 | 0.83 | LMNA (0.62) | LMNAMTORTP53GMNNALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797634-A1 | MODIFIED MRNAS ENCODING CELL-PENETRATING POLYPEPTIDES | Moderna Therapeutics, Inc. (US) | 2014-11-05 | — | — | EP | disclosed |
| EP-2691101-A2 | DELIVERY AND FORMULATION OF ENGINEERED NUCLEIC ACIDS | Moderna Therapeutics, Inc. (US) | 2014-02-05 | — | — | EP | disclosed |
| WO-2013101690-A1 | MODIFIED MRNAS ENCODING CELL-PENETRATING POLYPEPTIDES | modeRNA Therapeutics (US) | 2013-07-04 | — | — | WO | disclosed |
| WO-2012135805-A2 | DELIVERY AND FORMULATION OF ENGINEERED NUCLEIC ACIDS | modeRNA Therapeutics (US) | 2012-10-04 | — | — | WO | disclosed |