SCHEMBL12815367

SCHEMBL12815367

Cc1cc([Si](Cl)(c2cc(C)c(C)c(-c3ccccc3)c2)c2cc(C)c(C)c(-c3ccccc3)c2)cc(-c2ccccc2)c1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SQOR Q9Y6N5 1/20 0.42
KDM4E B2RXH2 3/20 0.42
ALDH1A1 P00352 2/20 0.42
MAPT P10636 2/20 0.42
RAB9A P51151 2/20 0.42
MEN1 O00255 1/20 0.42
POLB P06746 1/20 0.42
PKM P14618 1/20 0.42
KMT2A Q03164 1/20 0.42
ESR2 Q92731 1/20 0.40
CYP2A6 P11509 2/20 0.38
CYP2B6 P20813 1/20 0.38
PDE10A Q9Y233 1/20 0.38
PSMB5 P28074 2/20 0.37
PTGS1 P23219 1/20 0.37
AKT1 P31749 1/20 0.36
AKT2 P31751 1/20 0.36
ADORA3 P0DMS8 1/20 0.36
ADORA2A P29274 1/20 0.36
ADORA1 P30542 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12816144 0.92 SQOR (0.44) SQORKDM4EALDH1A1MAPTRAB9A
SCHEMBL12815489 0.85 ESR2 (0.38) SQORKDM4EALDH1A1MAPTRAB9A
SCHEMBL12816348 0.82 MEN1 (0.37) KDM4EALDH1A1MAPTRAB9AMEN1
SCHEMBL12816012 0.82 MEN1 (0.37) KDM4EALDH1A1MAPTRAB9AMEN1
SCHEMBL12816811 0.81 ESR2 (0.53) SQORESR2CYP2A6CYP2B6PSMB5
SCHEMBL12815897 0.81 ESR2 (0.40) SQORKDM4EALDH1A1MAPTRAB9A
SCHEMBL12816430 0.78 BACE1 (0.39) KDM4EALDH1A1MAPTMEN1KMT2A
SCHEMBL12816561 0.76 SQOR (0.44) SQORKDM4EALDH1A1MAPTRAB9A
SCHEMBL12815721 0.76 MAPT (0.37) KDM4EALDH1A1MAPTRAB9AMEN1
SCHEMBL9423370 0.75 PSMB5 (0.49) SQORKDM4EALDH1A1MAPTRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012133935-A1 METHOD FOR PRODUCING THE TRANSITION METAL COMPLEX, CATALYST FOR TRIMERIZATION, METHOD FOR PRODUCING 1-HEXENE, METHOD FOR PRODUCING THE SUBSTITUTED CYCLOPENTADIENE COMPOUND (3) SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-04 WO disclosed