Sugi Predict

Sugi Predict / Targets / SQOR

SQOR

Sulfide:quinone oxidoreductase, mitochondrial · Q9Y6N5 · SQOR on Sugi Atlas →

10,498 patent compounds predicted against SQOR, 3,677 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL4064410 SCHEMBL4064410 0.71 15/20
SCHEMBL4073012 SCHEMBL4073012 0.78 12/20
SCHEMBL4071272 SCHEMBL4071272 0.67 11/20
SCHEMBL4075279 SCHEMBL4075279 0.62 9/20
SCHEMBL5776622 SCHEMBL5776622 0.53 9/20
SCHEMBL2592972 SCHEMBL2592972 0.44 9/20
SCHEMBL2201824 SCHEMBL2201824 0.56 8/20
SCHEMBL4066196 SCHEMBL4066196 0.42 8/20
SCHEMBL4072588 SCHEMBL4072588 0.56 7/20
SCHEMBL3076231 SCHEMBL3076231 0.56 7/20
SCHEMBL2816528 SCHEMBL2816528 0.55 7/20
SCHEMBL4475072 SCHEMBL4475072 0.51 7/20
SCHEMBL3075624 SCHEMBL3075624 0.48 7/20
SCHEMBL1145692 SCHEMBL1145692 0.45 7/20
SCHEMBL5377959 SCHEMBL5377959 0.45 7/20
SCHEMBL4074633 SCHEMBL4074633 0.43 7/20
SCHEMBL395111 SCHEMBL395111 0.62 6/20
SCHEMBL5218636 SCHEMBL5218636 0.62 6/20
SCHEMBL1421642 SCHEMBL1421642 0.56 6/20
SCHEMBL396421 SCHEMBL396421 0.55 6/20

Clinical trials — most relevant to SQOR by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease PHASE3COMPLETED
Effect of Pioglitazone Administered to Patients With Friedreich's Ataxia: Proof of Concept PHASE3COMPLETED
Effect of Montelukast Versus Co Enzyme in Sepsis PHASE2/PHASE3COMPLETED
Testing the Combination of MLN4924 (Pevonedistat), Carboplatin, and Paclitaxel in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Who Have Previously Been Treated With Immunotherapy PHASE2ACTIVE_NOT_RECRUITING
Prevent Cardiac Surgery Associated AKI Trial PHASE2RECRUITING
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder PHASE2WITHDRAWN
Study About Safety and Efficacy of Coenzyme Q10 in Progressive Supranuclear Palsy PHASE2COMPLETED
The KHENEREXT Study PHASE2COMPLETED
Clinical Trial of 2-HOBA in Pulmonary Arterial Hypertension PHASE2NOT_YET_RECRUITING
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? PHASE1UNKNOWN
Open-Trial of EPI-743 for Adults With Tourette Syndrome PHASE1COMPLETED
Natural History Study of FDXR Mutation-related Mitochondriopathy nanCOMPLETED
Evaluation of Thiosulfate Enhanced Organ Preservation Solution in Kidney Transplantation nanRECRUITING
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
Mitoquines in COPD nanUNKNOWN
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Mitochondrial Function of Immune Cells in Sepsis nanCOMPLETED
Prognostic Value of (DHODH) Expression in (HGSOC): A Comparative Study Between Neoadjuvant and Adjuvant Chemotherapy Settings nanNOT_YET_RECRUITING
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione nanCOMPLETED
Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome nanCOMPLETED
Human Adaptation to High Altitude nanUNKNOWN
Spa Rehabilitation, Antioxidant and Bioenergetic Supportive Treatment of Patients With Post-Covid-19 Syndrome nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Mitochondrial Dysfunction in Autism Spectrum Disorder nanACTIVE_NOT_RECRUITING
Mitochondria Oxidative Stress and Vascular Health Study nanCOMPLETED
Effect of Diaphragm Stimulation During Surgery nanCOMPLETED
Multi-omics Study in Citrin Deficiency nanACTIVE_NOT_RECRUITING
Combined Effects of Statins and Exercise on Training Sensitive Health Markers nanCOMPLETED
Thiol/Disulphide Homeostasis in Unexplained Infertility nanCOMPLETED
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a SQOR binder may also engage these)

ProteinNameSimilarity
Q9R112 — 1.000 Q9R112 →
Q1JPL4 — 0.973 Q1JPL4 →
Q9ST62 — 0.971 Q9ST62 →
Q9SKT7 — 0.969 Q9SKT7 →
Q3TMV7 — 0.969 Q3TMV7 →
Q8WU10 — 0.967 Q8WU10 →
M1BYJ7 — 0.967 M1BYJ7 →
Q8BMF3 — 0.967 Q8BMF3 →
Q337B8 — 0.966 Q337B8 →
B4F6I3 — 0.965 B4F6I3 →
ME3 NADP-dependent malic enzyme, mitochondrial 0.965 landscape →
A5PJM4 — 0.964 A5PJM4 →
Q68FS6 — 0.963 Q68FS6 →
P28227 — 0.963 P28227 →
Q9WUM5 — 0.961 Q9WUM5 →
Q9DCM0 — 0.961 Q9DCM0 →
Q94522 — 0.961 Q94522 →
F4JJJ3 — 0.961 F4JJJ3 →
B5FXE5 — 0.961 B5FXE5 →
Q61941 — 0.961 Q61941 →
Q29554 — 0.961 Q29554 →
Q9UDR5 — 0.961 Q9UDR5 →
Q8BUE4 — 0.960 Q8BUE4 →
ME1 NADP-dependent malic enzyme 0.960 landscape →
A8E657 — 0.960 A8E657 →
PC Pyruvate carboxylase, mitochondrial 0.960 landscape →
A6QLJ3 — 0.960 A6QLJ3 →
O22854 — 0.960 O22854 →
P13086 — 0.960 P13086 →
P40927 — 0.959 P40927 →