SCHEMBL12816243

SCHEMBL12816243

Cc1cc(Cc2ccccc2)c(Cc2ccccc2)c([Si](Cl)(c2cc(C)cc(Cc3ccccc3)c2Cc2ccccc2)c2cc(C)cc(Cc3ccccc3)c2Cc2ccccc2)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2 P10415 1/20 0.38
BCL2L1 Q07817 1/20 0.38
PTGDR2 Q9Y5Y4 1/20 0.38
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
POLB P06746 1/20 0.36
CYP3A4 P08684 2/20 0.36
HPGD P15428 1/20 0.36
ALOX15 P16050 1/20 0.36
HIF1A Q16665 1/20 0.36
HSD17B10 Q99714 1/20 0.36
IDH1 O75874 2/20 0.36
CYP2D6 P10635 1/20 0.35
TSHR P16473 1/20 0.35
CYP2C19 P33261 1/20 0.35
GPR55 Q9Y2T6 1/20 0.35
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12822090 0.85 BCL2 (0.39) BCL2BCL2L1PTGDR2MEN1KMT2A
SCHEMBL12815667 0.85 TP53 (0.37) MEN1KMT2APOLBIDH1L3MBTL1
SCHEMBL12816652 0.81 BCL2 (0.38) BCL2BCL2L1MEN1KMT2APOLB
SCHEMBL12815362 0.81 BCL2 (0.38) BCL2BCL2L1MEN1KMT2APOLB
SCHEMBL12815370 0.80 CYP3A4 (0.43) BCL2BCL2L1MEN1KMT2ACYP3A4
SCHEMBL12816234 0.80 TSHR (0.43) BCL2BCL2L1MEN1KMT2APOLB
SCHEMBL12817080 0.80 BCL2 (0.42) BCL2BCL2L1MEN1KMT2ACYP3A4
SCHEMBL12816907 0.78 IDH1 (0.41) MEN1KMT2APOLBHPGDIDH1
SCHEMBL12816441 0.78 HTR2A (0.41) BCL2BCL2L1MEN1KMT2ACYP3A4
SCHEMBL12815932 0.77 BCL2 (0.38) BCL2BCL2L1MEN1KMT2APOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012133935-A1 METHOD FOR PRODUCING THE TRANSITION METAL COMPLEX, CATALYST FOR TRIMERIZATION, METHOD FOR PRODUCING 1-HEXENE, METHOD FOR PRODUCING THE SUBSTITUTED CYCLOPENTADIENE COMPOUND (3) SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-04 WO disclosed