SCHEMBL12816652

SCHEMBL12816652

Cc1c([Si](Cl)(c2cc(Cc3ccccc3)c(Cc3ccccc3)c(C)c2C)c2cc(Cc3ccccc3)c(Cc3ccccc3)c(C)c2C)cc(Cc2ccccc2)c(Cc2ccccc2)c1C

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2 P10415 1/20 0.38
BCL2L1 Q07817 1/20 0.38
MEN1 O00255 2/20 0.36
HPGD P15428 2/20 0.36
KMT2A Q03164 2/20 0.36
HSD17B10 Q99714 2/20 0.36
CYP3A4 P08684 1/20 0.36
ALOX15 P16050 1/20 0.36
HIF1A Q16665 1/20 0.36
CALM1 P0DP23 1/20 0.34
ALDH1A1 P00352 2/20 0.34
ALOX5 P09917 1/20 0.34
CNR2 P34972 1/20 0.34
GPR55 Q9Y2T6 1/20 0.34
LDHA P00338 1/20 0.34
LDHB P07195 1/20 0.34
KDM4E B2RXH2 2/20 0.33
GLA P06280 1/20 0.33
GAA P10253 1/20 0.33
HSD17B3 P37058 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12815362 0.87 BCL2 (0.38) BCL2BCL2L1MEN1HPGDKMT2A
SCHEMBL12815932 0.87 BCL2 (0.38) BCL2BCL2L1MEN1HPGDKMT2A
SCHEMBL12816245 0.82 CTRC (0.36) BCL2BCL2L1MEN1HPGDKMT2A
SCHEMBL12816243 0.81 BCL2 (0.38) BCL2BCL2L1MEN1HPGDKMT2A
SCHEMBL12816356 0.79 BCL2 (0.37) BCL2BCL2L1MEN1HPGDKMT2A
SCHEMBL12816855 0.79 CTRC (0.39) BCL2BCL2L1HPGDCALM1ALOX5
SCHEMBL12815758 0.79 IDH1 (0.36) MEN1HPGDKMT2AHSD17B10CALM1
SCHEMBL12815243 0.79 PTPN1 (0.41) BCL2BCL2L1MEN1HPGDKMT2A
SCHEMBL12822090 0.79 BCL2 (0.39) BCL2BCL2L1MEN1HPGDKMT2A
SCHEMBL12815656 0.78 CTRC (0.41) BCL2BCL2L1MEN1HPGDKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012133935-A1 METHOD FOR PRODUCING THE TRANSITION METAL COMPLEX, CATALYST FOR TRIMERIZATION, METHOD FOR PRODUCING 1-HEXENE, METHOD FOR PRODUCING THE SUBSTITUTED CYCLOPENTADIENE COMPOUND (3) SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2012-10-04 WO disclosed