Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4191188 | 0.90 | MAOA (0.47) | MAOAGAASMN1; SMN2NPSR1MAPT | |
| SCHEMBL9027751 | 0.83 | EPHX1 (0.48) | MAOAGAASMN1; SMN2MAPTEPHX1 | |
| SCHEMBL9027748 | 0.83 | EPHX1 (0.48) | MAOAGAASMN1; SMN2MAPTEPHX1 | |
| SCHEMBL1908699 | 0.83 | MAOA (0.43) | MAOAGAASMN1; SMN2NPSR1MAPT | |
| SCHEMBL9029685 | 0.83 | EPHX1 (0.48) | MAOAGAASMN1; SMN2MAPTEPHX1 | |
| SCHEMBL12819865 | 0.82 | SMN1; SMN2 (0.43) | SMN1; SMN2NPSR1MAPTKMT2AHPGD | |
| SCHEMBL21213732 | 0.81 | SMYD3 (0.49) | MAOAGAA | |
| SCHEMBL21198215 | 0.81 | SMYD3 (0.49) | MAOAGAA | |
| SCHEMBL16374937 | 0.81 | SMYD3 (0.49) | MAOAGAA | |
| SCHEMBL18629569 | 0.81 | NPSR1 (0.56) | SMN1; SMN2NPSR1MAPTKMT2AEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035417-A1 | HSP-90 BINDING COMPOUNDS, COMPOSITIONS THEREOF, AND THEIR USE FN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES | AEGERA THERAPEUTICS INC. (CA) | 2011-03-31 | — | — | WO | disclosed |