Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2953579 | 0.91 | HTT (0.57) | HTTALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL8393830 | 0.84 | HTT (0.63) | HTTALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL8395012 | 0.84 | HTT (0.69) | HTTALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL15715057 | 0.83 | MAPK1 (0.57) | HTTALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL15014622 | 0.83 | MAPK1 (0.57) | HTTALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL21161446 | 0.83 | HTT (0.49) | HTTALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL12820453 | 0.82 | HTT (0.72) | HTTALDH1A1SMN1; SMN2TSHRKDM4E | |
| SCHEMBL8396994 | 0.82 | HTT (0.72) | HTTALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL30423567 | 0.82 | HTT (0.72) | HTTALDH1A1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL8392442 | 0.82 | HTT (0.72) | HTTALDH1A1MAPTKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012126084-A1 | HSP-90 BINDING COMPOUNDS, COMPOSITIONS THEREOF, AND THEIR USE IΝ THE TREATMENT AND PREVENTION OF FUNGAL INFECTIONS | PHARMASCIENCE INC. (CA) | 2012-09-27 | — | — | WO | disclosed |
| WO-2011035416-A1 | HSP90 MODULATING COMPOUNDS, COMPOSITIONS, METHODS AND USES | AEGERA THERAPEUTICS INC. (CA) | 2011-03-31 | — | — | WO | disclosed |
| WO-2011035417-A1 | HSP-90 BINDING COMPOUNDS, COMPOSITIONS THEREOF, AND THEIR USE FN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES | AEGERA THERAPEUTICS INC. (CA) | 2011-03-31 | — | — | WO | disclosed |