Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 5/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | BUB1 | O43683 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PDE9A | O76083 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12820867 | 0.97 | HSD17B10 (0.41) | HSD17B10MAPK1ALDH1A1ALOX15SMN1; SMN2 | |
| SCHEMBL12820871 | 0.75 | MAPK1 (0.40) | HSD17B10MAPK1ALDH1A1TSHRNPSR1 | |
| SCHEMBL5462185 | 0.74 | SMN1; SMN2 (0.48) | ALDH1A1ALOX15SMN1; SMN2TSHRBRD4 | |
| SCHEMBL5004730 | 0.69 | MAPK1 (0.54) | HSD17B10MAPK1ALDH1A1TSHRNPSR1 | |
| SCHEMBL9803233 | 0.69 | HTT (0.44) | HSD17B10MAPK1ALDH1A1TSHRNPSR1 | |
| SCHEMBL3858956 | 0.66 | SMN1; SMN2 (0.58) | HSD17B10ALDH1A1ALOX15SMN1; SMN2TSHR | |
| SCHEMBL11593915 | 0.65 | SMN1; SMN2 (0.62) | HSD17B10ALDH1A1ALOX15SMN1; SMN2TSHR | |
| SCHEMBL1220108 | 0.64 | HSD17B10 (0.42) | HSD17B10MAPK1ALDH1A1TSHRNPSR1 | |
| SCHEMBL23537362 | 0.63 | HPGD (0.47) | HSD17B10MAPK1ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL20567835 | 0.63 | MAPK1 (0.66) | HSD17B10MAPK1ALDH1A1ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035416-A1 | HSP90 MODULATING COMPOUNDS, COMPOSITIONS, METHODS AND USES | AEGERA THERAPEUTICS INC. (CA) | 2011-03-31 | — | — | WO | disclosed |