Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | BUB1 | O43683 | 10/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1220108 | 0.75 | HSD17B10 (0.42) | HTTMAPK1BRD4BUB1HSD17B10 | |
| SCHEMBL5004730 | 0.73 | MAPK1 (0.54) | MAPK1BRD4BUB1HSD17B10MEN1 | |
| SCHEMBL9802765 | 0.71 | PTK2 (0.47) | MAPK1BRD4BUB1HSD17B10ALDH1A1 | |
| SCHEMBL12820867 | 0.69 | HSD17B10 (0.41) | MAPK1BRD4BUB1HSD17B10MEN1 | |
| SCHEMBL12820992 | 0.69 | HSD17B10 (0.41) | MAPK1BRD4BUB1HSD17B10MEN1 | |
| SCHEMBL10796689 | 0.68 | HTT (0.46) | HTTMAPK1BRD4HSD17B10MEN1 | |
| SCHEMBL4325559 | 0.68 | CYP2C19 (0.45) | HTTBRD4BUB1HSD17B10ALPL | |
| SCHEMBL370336 | 0.68 | TDP1 (0.46) | HTTMAPK1BRD4HSD17B10MEN1 | |
| SCHEMBL14896164 | 0.68 | BUB1 (0.44) | MAPK1BUB1ALPL | |
| SCHEMBL14896227 | 0.67 | ALPL (0.49) | HTTBUB1ALPLALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5068334-A | Analgesics and antipyretics | KARL THOMAE GMBH (DE) | 1991-11-26 | — | — | US | disclosed |
| EP-0338228-A2 | Use of quinoline-2,5-diones in a medicament having an analgesic, antipyretic and/or antiphlogistic activity | Dr. Karl Thomae GmbH (DE) | 1989-10-25 | — | — | EP | disclosed |