Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.59 |
| ▸ | TDP2 | O95551 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 6/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12822152 | 0.91 | FGFR1 (0.60) | FGFR1TDP2PPARGAKR1C3ALDH1A1 | |
| SCHEMBL12822160 | 0.91 | FGFR1 (0.62) | FGFR1TDP2GSK3BALDH1A1HPGD | |
| SCHEMBL12822123 | 0.87 | FGFR1 (0.78) | FGFR1PPARGALDH1A1HPGDMAPK1 | |
| SCHEMBL12822175 | 0.85 | FGFR1 (0.61) | FGFR1PPARGAKR1C3 | |
| SCHEMBL12822333 | 0.84 | FGFR1 (0.62) | FGFR1CDK1GSK3BPRKCQMAP3K1 | |
| SCHEMBL12822386 | 0.84 | FGFR1 (0.76) | FGFR1PPARGAKR1C3ALDH1A1HPGD | |
| SCHEMBL12822187 | 0.82 | FGFR1 (0.62) | FGFR1ALDH1A1HPGDMAPK1HTT | |
| SCHEMBL12822071 | 0.81 | FGFR1 (0.64) | FGFR1HPGD | |
| SCHEMBL12822295 | 0.81 | FGFR1 (0.64) | FGFR1PPARGAKR1C3ALDH1A1HPGD | |
| SCHEMBL12821909 | 0.80 | FGFR1 (0.66) | FGFR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012131501-A1 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AS COT KINASE INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2012-10-04 | — | — | WO | claimed |