Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.62 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12822152 | 0.91 | FGFR1 (0.60) | FGFR1THRBHPGDALDH1A1MAPK1 | |
| SCHEMBL12821995 | 0.91 | FGFR1 (0.59) | FGFR1HPGDALDH1A1MAPK1HTT | |
| SCHEMBL12821909 | 0.90 | FGFR1 (0.66) | FGFR1THRBPTPN11HPGD | |
| SCHEMBL12822123 | 0.87 | FGFR1 (0.78) | FGFR1THRBHPGDALDH1A1MAPK1 | |
| SCHEMBL12822187 | 0.84 | FGFR1 (0.62) | FGFR1HPGDALDH1A1MAPK1HTT | |
| SCHEMBL15288227 | 0.84 | FGFR1 (0.57) | FGFR1THRBPTPN11 | |
| SCHEMBL25297465 | 0.83 | FGFR1 (0.71) | FGFR1THRBHPGDALDH1A1GSK3B | |
| SCHEMBL30440825 | 0.83 | FGFR1 (0.71) | FGFR1THRBHPGDALDH1A1GSK3B | |
| SCHEMBL12822175 | 0.81 | FGFR1 (0.61) | FGFR1PARP15PARP10PARP2CHEK2 | |
| SCHEMBL12822333 | 0.80 | FGFR1 (0.62) | FGFR1THRBHPGDGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012131501-A1 | SUBSTITUTED BENZIMIDAZOLE COMPOUNDS AS COT KINASE INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2012-10-04 | — | — | WO | claimed |