Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 7/20 | 0.59 |
| ▸ | CLK1 | P49759 | 10/20 | 0.58 |
| ▸ | CDC7 | O00311 | 3/20 | 0.58 |
| ▸ | DBF4 | Q9UBU7 | 2/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.57 |
| ▸ | FLT1 | P17948 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.54 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.54 |
| ▸ | EEF2K | O00418 | 1/20 | 0.52 |
| ▸ | PI4KA | P42356 | 1/20 | 0.46 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.46 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23327861 | 0.83 | CHEK2 (0.57) | LIMK1CLK1CDC7DBF4CHEK2 | |
| SCHEMBL31683835 | 0.83 | CHEK2 (0.57) | LIMK1CLK1CDC7DBF4CHEK2 | |
| SCHEMBL23353057 | 0.75 | CHEK2 (0.49) | LIMK1CLK1CDC7DBF4CHEK2 | |
| SCHEMBL23353114 | 0.75 | CHEK2 (0.49) | LIMK1CLK1CDC7DBF4CHEK2 | |
| SCHEMBL23352787 | 0.75 | CHEK2 (0.49) | LIMK1CLK1CDC7DBF4CHEK2 | |
| SCHEMBL23352803 | 0.75 | CHEK2 (0.49) | LIMK1CLK1CDC7DBF4CHEK2 | |
| SCHEMBL4901470 | 0.74 | LIMK1 (1.00) | LIMK1CLK1CDC7DBF4KDM4E | |
| SCHEMBL12970349 | 0.73 | CLK1 (1.00) | LIMK1CLK1CDC7DBF4 | |
| SCHEMBL31462912 | 0.73 | CHEK2 (1.00) | CLK1CHEK2FLT1KDM4ENPC1 | |
| SCHEMBL23458905 | 0.73 | CHEK2 (1.00) | CLK1CHEK2FLT1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012131297-A1 | PYRIDO [3',2' :4,5] THIENO [3, 2-D] PYRIMIDIN- 4 - YLAMINE DERIVATIVES AND THEIR THERAPEUTICAL USE | BAELL JONATHAN BAYLDON (AU) | 2012-10-04 | — | — | WO | disclosed |