Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 1.00 |
| ▸ | FLT1 | P17948 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | IDE | P14735 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23458905 | 1.00 | CHEK2 (1.00) | CHEK2FLT1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL31683835 | 0.73 | CHEK2 (0.57) | CHEK2FLT1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL12822381 | 0.73 | LIMK1 (0.59) | CHEK2FLT1KDM4ENPC1MAPT | |
| SCHEMBL23327861 | 0.73 | CHEK2 (0.57) | CHEK2FLT1SMN1; SMN2KDM4EKMT2A | |
| SCHEMBL23378444 | 0.72 | ALDH1A1 (0.66) | CHEK2FLT1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL23378472 | 0.69 | ALDH1A1 (0.65) | CHEK2FLT1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL28426308 | 0.69 | TLR8 (0.73) | CHEK2FLT1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL23378352 | 0.68 | ALDH1A1 (0.64) | CHEK2FLT1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL8421424 | 0.66 | SOD1 (0.56) | CHEK2FLT1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL23352787 | 0.66 | CHEK2 (0.49) | CHEK2FLT1KMT2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250111889-A1 | DE NOVO DESIGNED MACROCYCLIC OLIGOAMIDES | UNIVERSITY OF WASHINGTON | 2025-04-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250111889-A1 | DE NOVO DESIGNED MACROCYCLIC OLIGOAMIDES | DHFR, CCNH, ODC1 | CHEK2 1883/4885FLT1 1688/4885LMNA 1387/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.