Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 9/20 | 0.65 |
| ▸ | PDE1A | P54750 | 4/20 | 0.65 |
| ▸ | PDE1B | Q01064 | 4/20 | 0.65 |
| ▸ | PDE1C | Q14123 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GUSB | P08236 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MGAM | O43451 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SI | P14410 | 1/20 | 0.40 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13533558 | 0.82 | PDE5A (0.77) | PDE5APDE1APDE1BPDE1CGUSB | |
| SCHEMBL1513983 | 0.81 | PDE5A (0.60) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL972561 | 0.79 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL5916396 | 0.76 | PDE5A (0.59) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL12823745 | 0.75 | PDE5A (0.57) | PDE5APDE1APDE1BPDE1CHPGD | |
| SCHEMBL8358527 | 0.74 | PDE5A (0.53) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL5916404 | 0.74 | PDE5A (0.53) | PDE5APDE1APDE1BPDE1CKDM4E | |
| SCHEMBL12823742 | 0.73 | PDE5A (0.51) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL12823968 | 0.73 | PDE5A (0.63) | PDE5APDE1APDE1BPDE1C | |
| SCHEMBL5619914 | 0.73 | PDE5A (0.52) | PDE5APDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295436-A1 | 2-Phenyl-subsitituted Imidazotriazinones as Phosphodiesterase V inhibitors | Bayer Schering Pharma AG (DE) | 2011-03-16 | — | — | EP | disclosed |