Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.59 |
| ▸ | PDE1A | P54750 | 3/20 | 0.59 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.59 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.59 |
| ▸ | HTT | P42858 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KRAS | P01116 | 3/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1513983 | 0.81 | PDE5A (0.60) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL8358527 | 0.77 | PDE5A (0.53) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL12824019 | 0.76 | PDE5A (0.65) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL8358658 | 0.75 | PDE5A (0.52) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL13533558 | 0.74 | PDE5A (0.77) | PDE5APDE1APDE1BPDE1CHTT | |
| SCHEMBL972561 | 0.74 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL8358661 | 0.74 | PDE5A (0.53) | PDE5APDE1APDE1BPDE1CRAB9A | |
| SCHEMBL5916404 | 0.74 | PDE5A (0.53) | PDE5APDE1APDE1BPDE1CALDH1A1 | |
| SCHEMBL5233623 | 0.73 | HTT (0.50) | PDE5AHTTALDH1A1L3MBTL1RAB9A | |
| SCHEMBL5619914 | 0.73 | PDE5A (0.52) | PDE5APDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060166992-A1 | Heterocyclically substituted imidazotriazines | BAYER HEALTHCARE A G (DE) | 2006-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060166992-A1 | Heterocyclically substituted imidazotriazines | SNCA, PARK7, TPMT | PDE5A 2360/4885PDE1A 2215/4885PDE1B 2617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.