Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.64 |
| ▸ | CDK2 | P24941 | 3/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.64 |
| ▸ | PLK4 | O00444 | 2/20 | 0.64 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.64 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.64 |
| ▸ | PRKCG | P05129 | 2/20 | 0.64 |
| ▸ | CDK1 | P06493 | 2/20 | 0.64 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.64 |
| ▸ | CLK2 | P49760 | 2/20 | 0.64 |
| ▸ | GSK3B | P49841 | 2/20 | 0.64 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.64 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.64 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.64 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.64 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.64 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.64 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.64 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12825312 | 0.88 | CDK2 (0.60) | DYRK1ACDK2MAPK1PLK4MAPK13 | |
| SCHEMBL12824983 | 0.88 | ROCK2 (0.69) | DYRK1ACDK2MAPK1PLK4MAPK13 | |
| SCHEMBL12824757 | 0.86 | MAPK1 (0.65) | DYRK1ACDK2MAPK1PLK4MAPK13 | |
| SCHEMBL12825386 | 0.86 | CDK2 (0.60) | DYRK1ACDK2MAPK1PLK4MAPK13 | |
| SCHEMBL12824984 | 0.86 | ROCK2 (0.67) | DYRK1ACDK2MAPK1PLK4MAPK13 | |
| SCHEMBL12825861 | 0.85 | ROCK2 (0.57) | DYRK1ACDK2MAPK1PLK4MAPK13 | |
| SCHEMBL12824527 | 0.84 | MAPK1 (0.58) | DYRK1ACDK2MAPK1PLK4MAPK13 | |
| SCHEMBL12825860 | 0.84 | ROCK2 (0.57) | DYRK1ACDK2MAPK1PLK4MAPK13 | |
| SCHEMBL12826062 | 0.83 | AURKB (0.64) | DYRK1ACDK2MAPK1PLK4MAPK13 | |
| SCHEMBL12825525 | 0.83 | GSK3B (0.56) | DYRK1ACDK2MAPK1PLK4MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295412-A1 | Indazole compounds useful as protein kinase inhibitors | Vertex Pharmaceuticals Incorporated (US) | 2011-03-16 | — | — | EP | disclosed |