Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 7/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 4/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12826642 | 0.81 | ALOX5AP (0.36) | ALOX5APORAI1ABL1KLKB1FEN1 | |
| SCHEMBL12825540 | 0.72 | ORAI1 (0.49) | ORAI1ABL1KLKB1 | |
| SCHEMBL1463839 | 0.69 | ORAI1 (0.35) | ALOX5APORAI1ABL1FEN1SCN9A | |
| SCHEMBL34471273 | 0.66 | JAK2 (0.50) | ALOX5APFEN1JAK2PIK3CA | |
| SCHEMBL21463467 | 0.64 | NNMT (0.45) | ORAI1ABL1JAK2PIK3CA | |
| SCHEMBL30615694 | 0.64 | NNMT (0.45) | ORAI1ABL1JAK2PIK3CA | |
| SCHEMBL1462787 | 0.61 | ABL1 (0.39) | ALOX5APORAI1ABL1PIK3CA | |
| SCHEMBL15751031 | 0.61 | NNMT (0.51) | ALOX5APABL1KLKB1FEN1JAK2 | |
| SCHEMBL12826290 | 0.60 | ABL1 (0.37) | ALOX5APORAI1ABL1PIK3CA | |
| SCHEMBL1459926 | 0.59 | ORAI1 (0.55) | ORAI1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011036130-A1 | INDOLE DERIVATIVES AS CRAC MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-31 | — | — | WO | disclosed |