⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL158449 | 0.74 | — | — | |
| SCHEMBL3991 | 0.72 | — | — | |
| SCHEMBL135028 | 0.72 | — | — | |
| SCHEMBL9450629 | 0.70 | — | — | |
| SCHEMBL7644924 | 0.70 | — | — | |
| SCHEMBL7648163 | 0.70 | — | — | |
| SCHEMBL9561983 | 0.70 | — | — | |
| SCHEMBL9650164 | 0.69 | NPC1 (0.35) | — | |
| SCHEMBL16720251 | 0.69 | CA2 (0.35) | — | |
| SCHEMBL1968232 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 321 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4232444-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2023-08-30 | — | — | EP | claimed |
| WO-2022083569-A1 | HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2022-04-28 | — | — | WO | claimed |
| CN-114213353-A | Aryl-oxazole-oxazoline compound and preparation method and application thereof | 贵州大学 | 2022-03-22 | — | — | CN | claimed |
| EP-3342767-B1 | PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC (US) | 2021-04-14 | — | — | EP | claimed |
| US-10689372-B2 | Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto | ARENA PHARMACEUTICALS, INC. (US) | 2020-06-23 | — | — | US | claimed |
| EP-3019490-B1 | N,6-BIS(ARYL OR HETEROARYL)-1,3,5-TRIAZINE-2,4-DIAMINE COMPOUNDS AS IDH2 MUTANTS INHIBITORS FOR THE TREATMENT OF CANCER | AGIOS PHARMACEUTICALS INC (US) | 2020-06-03 | — | — | EP | claimed |
| US-20190270731-A1 | PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. | 2019-09-05 | — | — | US | claimed |
| US-10111878-B2 | N,6-bis(aryl or heteroaryl)-1,3,5-triazine-2,4-diamine compounds as IDH2 mutants inhibitors for the treatment of cancer | AGIOS PHARMACEUTICALS, INC. (US) | 2018-10-30 | — | — | US | claimed |
| EP-3342767-A1 | PYRAZOLYL SUBSTITUTED CARBONIC ACID DERIVATIVES AS MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2018-07-04 | — | — | EP | claimed |
| US-20170348318-A1 | N,6-BIS(ARYL OR HETEROARYL)-1,3,5-TRIAZINE-2,4-DIAMINE COMPOUNDS AS IDH2 MUTANTS INHIBITORS FOR THE TREATMENT OF CANCER | SERVIER PHARMACEUTICALS LLC | 2017-12-07 | — | — | US | claimed |
| US-20060025345-A1 | Substituted ethane-1,2-diamines for the treatment of Alzheimer's disease | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2006-02-02 | — | — | US | claimed |
| WO-2005113582-A1 | SUBSTITUTED ETHANE-1,2-DIAMINES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-12-01 | — | — | WO | claimed |
| US-20050187217-A1 | Compositions useful as inhibitors of voltage-gated ion channels | VERTEX PHARMACEUTICALS INCORPORATED | 2005-08-25 | — | — | US | claimed |
| CN-1184250-C | Novel polyhydroxyalkanoate having unit of substituted or unsubstituted (phenylmethyl) sulfanyl structure in side chain, and method for producing same | CANON KK (JP) | 2005-01-12 | — | — | CN | claimed |
| CN-1424337-A | Novel polyhydroxyalkanoate having unit of substituted or unsubstituted (phenylmethyl) sulfanyl structure in side chain, and method for producing same | CANON KK (JP) | 2003-06-18 | — | — | CN | claimed |
| US-5707844-A | QUINOLINECARBOXYLIC ACID SALTS AS HAPTAN SPECIFIC ANTIBODIES | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-01-13 | — | — | US | claimed |
| EP-0702726-A1 | IMMUNOASSAY REAGENTS AND METHODS FOR DETECTING BREQUINAR AND ANALOGS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-03-27 | — | — | EP | claimed |
| US-5393891-A | Useful as standards in testing for presence of quinoline carboxylic acids | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-02-28 | — | — | US | claimed |
| WO-1994029478-A1 | IMMUNOASSAY REAGENTS AND METHODS FOR DETECTING BREQUINAR AND ANALOGS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-12-22 | — | — | WO | claimed |
| US-4226864-A | BACTERICIDES, ANTIBIOTICS | SHIONOGI & CO., LTD. (JP) | 1980-10-07 | — | — | US | claimed |