Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 10/20 | 0.70 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | ECE1 | P42892 | 3/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194902 | 0.91 | CFTR (0.72) | CFTRTHRBTHRAECE1NR1I2 | |
| SCHEMBL19753219 | 0.91 | CFTR (0.75) | CFTRTHRBTHRAECE1NR1I2 | |
| SCHEMBL14403854 | 0.91 | CFTR (0.67) | CFTRTHRBTHRAECE1NR1I2 | |
| SCHEMBL17030579 | 0.89 | CFTR (0.67) | CFTRTHRBTHRANR1I2HTR2A | |
| SCHEMBL20194994 | 0.89 | CFTR (0.67) | CFTRTHRBTHRAECE1NR1I2 | |
| SCHEMBL23506674 | 0.89 | CFTR (0.67) | CFTRTHRBTHRAECE1NR1I2 | |
| SCHEMBL13365163 | 0.89 | CFTR (0.77) | CFTRTHRBTHRAECE1NR1I2 | |
| SCHEMBL20194863 | 0.89 | CFTR (0.69) | CFTRECE1NR1I2HTR2APDE4D | |
| SCHEMBL19753122 | 0.89 | CFTR (0.69) | CFTRTHRBTHRAECE1NR1I2 | |
| SCHEMBL14403579 | 0.88 | CFTR (0.73) | CFTRTHRBTHRAECE1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110071206-A1 | Modulators of ATP-Binding Cassette Transporters | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110071206-A1 | Modulators of ATP-Binding Cassette Transporters | CFTR, ABCB1, ABCC2 | CFTR 1/4885ALOX5 3605/4885EPHX2 2241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.