Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.66 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.66 |
| ▸ | CLK1 | P49759 | 3/20 | 0.66 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.66 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.66 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.63 |
| ▸ | KIT | P10721 | 4/20 | 0.59 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | AXL | P30530 | 1/20 | 0.53 |
| ▸ | CDK8 | P49336 | 1/20 | 0.53 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | SGK1 | O00141 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320542 | 0.84 | DYRK1A (0.59) | NTRK1DYRK1ACLK1DYRK2DYRK1B | |
| SCHEMBL20408723 | 0.84 | KIT (0.59) | NTRK1DYRK1ACLK1DYRK2DYRK1B | |
| SCHEMBL1800807 | 0.84 | AXL (0.73) | NTRK1MAP3K11KITGSK3BAXL | |
| SCHEMBL8320227 | 0.81 | KIT (0.67) | DYRK1AMAP3K11KITPIK3CA | |
| SCHEMBL3764839 | 0.81 | AXL (0.83) | NTRK1DYRK1ACLK1DYRK2DYRK1B | |
| SCHEMBL8320268 | 0.81 | KIT (0.61) | NTRK1DYRK1ACLK1DYRK2DYRK1B | |
| SCHEMBL1487612 | 0.81 | MAPK8 (0.67) | NTRK1DYRK1ACLK1DYRK2DYRK1B | |
| SCHEMBL25971496 | 0.80 | BRD4 (0.47) | NTRK1DYRK1ACLK1DYRK2DYRK1B | |
| SCHEMBL18576768 | 0.80 | NTRK1 (1.00) | NTRK1DYRK1ACLK1DYRK2DYRK1B | |
| SCHEMBL722564 | 0.78 | MAP3K11 (1.00) | NTRK1DYRK1ACLK1DYRK2DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295433-A2 | JNK inhibitors | Eisai R&D Management Co., Ltd. (JP) | 2011-03-16 | — | — | EP | disclosed |