Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.53 |
| ▸ | SGK1 | O00141 | 3/20 | 0.49 |
| ▸ | AXL | P30530 | 3/20 | 0.49 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.48 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321175 | 0.91 | KDM1A (0.55) | MAPK8MAPK9MAPK10SGK1AXL | |
| SCHEMBL8322707 | 0.84 | MAPK8 (0.61) | MAPK8MAPK9MAPK10SGK1AXL | |
| SCHEMBL12829932 | 0.83 | MAPK8 (0.57) | MAPK8MAPK9MAPK10SGK1AXL | |
| SCHEMBL8320314 | 0.82 | MAPK8 (0.59) | MAPK8MAPK9MAPK10SGK1AXL | |
| SCHEMBL8313907 | 0.82 | ROCK2 (0.62) | MAPK8MAPK9MAPK10SGK1AXL | |
| SCHEMBL13745344 | 0.82 | MAPK8 (0.58) | MAPK8MAPK9MAPK10SGK1AXL | |
| SCHEMBL8319993 | 0.82 | MAPK8 (0.55) | MAPK8MAPK9MAPK10SGK1AXL | |
| SCHEMBL8322829 | 0.81 | GSK3B (0.53) | MAPK8MAPK9MAPK10SGK1AXL | |
| SCHEMBL8313403 | 0.81 | MAPK8 (0.51) | MAPK8MAPK9MAPK10SGK1AXL | |
| SCHEMBL8323358 | 0.81 | MAPK8 (0.54) | MAPK8MAPK9MAPK10SGK1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295433-A2 | JNK inhibitors | Eisai R&D Management Co., Ltd. (JP) | 2011-03-16 | — | — | EP | disclosed |