Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12830298 | 0.89 | GRM5 (0.56) | GRM5 | |
| SCHEMBL4475675 | 0.89 | TSHR (0.59) | GRM5SMN1; SMN2LMNAFFAR4TSHR | |
| SCHEMBL4478047 | 0.88 | GRM5 (0.59) | GRM5SMN1; SMN2LMNAFFAR4TSHR | |
| SCHEMBL12830517 | 0.88 | GRM5 (0.64) | GRM5SMN1; SMN2LMNATSHRALDH1A1 | |
| SCHEMBL12830291 | 0.87 | GRM5 (0.67) | GRM5SMN1; SMN2LMNATSHRKMT2A | |
| SCHEMBL12412147 | 0.87 | GRM5 (0.61) | GRM5SMN1; SMN2LMNATSHRALDH1A1 | |
| SCHEMBL12412646 | 0.87 | GRM5 (0.77) | GRM5KMT2A | |
| SCHEMBL6926437 | 0.87 | GRM5 (0.76) | GRM5SMN1; SMN2LMNATSHRALDH1A1 | |
| SCHEMBL12830285 | 0.87 | NPC1 (0.56) | GRM5SMN1; SMN2LMNATSHRKMT2A | |
| SCHEMBL12412157 | 0.85 | GRM5 (0.63) | GRM5SMN1; SMN2LMNAFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035214-A1 | SUBSTITUTED PHENYLAMINE CARBOXAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | VANDERBILT UNIVERSITY (US) | 2011-03-24 | — | — | WO | disclosed |