Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12830517 | 0.92 | GRM5 (0.64) | GRM5ALDH1A1SMN1; SMN2LMNATSHR | |
| SCHEMBL6926476 | 0.88 | GRM5 (0.74) | GRM5 | |
| SCHEMBL12830291 | 0.87 | GRM5 (0.67) | GRM5SMN1; SMN2LMNATSHR | |
| SCHEMBL12830278 | 0.87 | GRM5 (0.58) | GRM5ALDH1A1SMN1; SMN2LMNATSHR | |
| SCHEMBL12416360 | 0.86 | GRM5 (0.76) | GRM5ALDH1A1SMN1; SMN2LMNATSHR | |
| SCHEMBL1487647 | 0.86 | GRM5 (1.00) | GRM5ALDH1A1 | |
| SCHEMBL6925812 | 0.86 | GRM5 (1.00) | GRM5ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL12830285 | 0.84 | NPC1 (0.56) | GRM5SMN1; SMN2LMNATSHR | |
| SCHEMBL7078083 | 0.84 | LMNA (0.69) | ALDH1A1LMNATSHR | |
| SCHEMBL6926454 | 0.83 | GRM5 (1.00) | GRM5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035174-A1 | SUBSTITUTED HETEROARYLAMINE CARBOXAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | VANDERBILT UNIVERSITY (US) | 2011-03-24 | — | — | WO | disclosed |