Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | BTK | Q06187 | 4/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | ULK1 | O75385 | 1/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BLK | P51451 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12412451 | 0.88 | KCNK3 (0.58) | GRM5CSF1RKCNK3KCNK9MEN1 | |
| SCHEMBL12412769 | 0.87 | GRM5 (0.70) | GRM5CSF1RMEN1KMT2A | |
| SCHEMBL12504639 | 0.87 | GRM5 (0.53) | GRM5CSF1RKCNK3KCNK9MEN1 | |
| SCHEMBL12412766 | 0.87 | GRM5 (0.70) | GRM5CSF1RKCNK3KCNK9MEN1 | |
| SCHEMBL12830501 | 0.87 | GRM5 (0.62) | GRM5PTGS1BTKCSF1RULK1 | |
| SCHEMBL12830275 | 0.87 | PTGS1 (0.57) | GRM5PTGS1BTKKCNK3KCNK9 | |
| SCHEMBL12830487 | 0.86 | GRM5 (0.65) | GRM5BTKCSF1RKCNK3MEN1 | |
| SCHEMBL12412768 | 0.85 | GRM5 (0.72) | GRM5 | |
| SCHEMBL12412453 | 0.85 | GRM5 (0.58) | GRM5CSF1RKCNK3KCNK9 | |
| SCHEMBL12830299 | 0.83 | GRM5 (0.59) | GRM5CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035214-A1 | SUBSTITUTED PHENYLAMINE CARBOXAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | VANDERBILT UNIVERSITY (US) | 2011-03-24 | — | — | WO | disclosed |