Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 6/20 | 0.65 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.54 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | GFER | P55789 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 2/20 | 0.50 |
| ▸ | ATR | Q13535 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | BLK | P51451 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6927293 | 0.92 | GRM5 (0.77) | GRM5CSF1RBRAFL3MBTL1ALDH1A1 | |
| SCHEMBL12830501 | 0.90 | GRM5 (0.62) | GRM5CSF1RBTK | |
| SCHEMBL12830299 | 0.88 | GRM5 (0.59) | GRM5CSF1RBRAFL3MBTL1ALDH1A1 | |
| SCHEMBL12411966 | 0.87 | GRM5 (0.66) | GRM5CSF1RBRAFKCNK3L3MBTL1 | |
| SCHEMBL12412670 | 0.86 | GRM5 (0.85) | GRM5CSF1RBRAFKCNK3L3MBTL1 | |
| SCHEMBL2182181 | 0.86 | GRM5 (0.75) | GRM5CSF1RBRAFKCNK3MEN1 | |
| SCHEMBL12830293 | 0.86 | GRM5 (0.53) | GRM5CSF1RKCNK3MEN1KMT2A | |
| SCHEMBL12830491 | 0.86 | GRM5 (0.53) | GRM5CSF1RBRAFKCNK3ALDH1A1 | |
| SCHEMBL12412666 | 0.84 | GRM5 (0.86) | GRM5CSF1RBRAFALDH1A1 | |
| SCHEMBL12411962 | 0.84 | GRM5 (0.70) | GRM5CSF1RBRAFKCNK3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035214-A1 | SUBSTITUTED PHENYLAMINE CARBOXAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | VANDERBILT UNIVERSITY (US) | 2011-03-24 | — | — | WO | disclosed |