Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.34 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | PRKCG | P05129 | 1/20 | 0.34 |
| ▸ | PRKCB | P05771 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 1/20 | 0.34 |
| ▸ | PRKCH | P24723 | 1/20 | 0.34 |
| ▸ | PRKCI | P41743 | 1/20 | 0.34 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.34 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.34 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1494641 | 0.86 | BRAF (0.59) | BRAFCDC7EIF2AK2 | |
| SCHEMBL6522934 | 0.86 | BRAF (0.43) | BRAFCDC7MAPK13MAPK12MAPK11 | |
| SCHEMBL6522717 | 0.86 | BRAF (0.43) | BRAFCDC7MAPK13MAPK12MAPK11 | |
| SCHEMBL1494675 | 0.79 | BRAF (0.53) | BRAF | |
| SCHEMBL6525657 | 0.77 | BRAF (0.63) | BRAF | |
| Ammonia Solution, Strong SCHEMBL6522718 | 0.74 | BRAF (0.33) | BRAF | |
| SCHEMBL12830997 | 0.72 | BRAF (0.82) | BRAF | |
| SCHEMBL12831014 | 0.72 | BRAF (0.82) | BRAFMAPK14 | |
| SCHEMBL7471338 | 0.65 | MKNK1 (0.51) | CXCR4PRKD3EGFRPRKCGPRKCB | |
| SCHEMBL5771486 | 0.64 | MAPK13 (0.63) | BRAFMAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011023773-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-03-03 | — | — | WO | disclosed |