Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11923834 | 0.86 | MEN1 (1.00) | MEN1KMT2AGAASMN1; SMN2GRM5 | |
| SCHEMBL30883376 | 0.86 | MEN1 (1.00) | MEN1KMT2AGAASMN1; SMN2GRM5 | |
| SCHEMBL31260453 | 0.82 | MEN1 (0.79) | MEN1KMT2AGAASMN1; SMN2HTR2A | |
| SCHEMBL16519579 | 0.82 | MEN1 (0.79) | MEN1KMT2AGAASMN1; SMN2GRM5 | |
| SCHEMBL24869723 | 0.78 | MEN1 (0.77) | MEN1KMT2AGAASMN1; SMN2GRM5 | |
| SCHEMBL30875685 | 0.78 | MEN1 (0.77) | MEN1KMT2AGAASMN1; SMN2GRM5 | |
| Thalifoline SCHEMBL29961712 | 0.78 | MEN1 (0.77) | MEN1KMT2AGAASMN1; SMN2HTR2B | |
| SCHEMBL25946921 | 0.77 | MEN1 (0.75) | MEN1KMT2AGAASMN1; SMN2GRM5 | |
| SCHEMBL14980800 | 0.75 | MEN1 (0.73) | MEN1KMT2AGAASMN1; SMN2GRM5 | |
| SCHEMBL6074018 | 0.75 | MEN1 (0.73) | MEN1KMT2AGAASMN1; SMN2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011025706-A2 | HETEROCYCLIC AMIDE COMPOUNDS AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2011-03-03 | — | — | WO | disclosed |