SCHEMBL12831776

SCHEMBL12831776

CN(C)Cc1ccccc1C(F)(F)F

nearest known ligand 0.50

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 14/20 0.50
SLC6A2 P23975 13/20 0.50
IDO1 P14902 2/20 0.50
POLQ O75417 1/20 0.50
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
SLC6A3 Q01959 5/20 0.48
ACHE P22303 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22651953 0.82 SLC6A2 (0.48) SLC6A4SLC6A2IDO1POLQSLC6A3
SCHEMBL12124971 0.82 SLC6A2 (0.54) SLC6A4SLC6A2IDO1POLQSLC6A3
SCHEMBL23961646 0.81 SLC6A2 (0.55) SLC6A4SLC6A2IDO1POLQSLC6A3
SCHEMBL11625501 0.81 SLC6A4 (0.43) SLC6A4SLC6A2IDO1POLQCYP3A4
SCHEMBL6907315 0.81 CYP2D6 (0.44) SLC6A4SLC6A2POLQCYP3A4CYP2D6
SCHEMBL8310680 0.81 CYP2C19 (0.46) SLC6A4SLC6A2CYP3A4CYP2D6SLC6A3
SCHEMBL8530348 0.81 SLC6A4 (0.64) SLC6A4SLC6A2SLC6A3
SCHEMBL21123197 0.80 TAAR1 (0.58) SLC6A4SLC6A2IDO1POLQACHE
SCHEMBL18137967 0.80 SLC6A2 (0.56) SLC6A4SLC6A2IDO1POLQSLC6A3
SCHEMBL11859509 0.80 CYP3A4 (0.50) SLC6A4SLC6A2POLQCYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117531520-A Catalyst and preparation method and application thereof 厦门大学 2024-02-09 CN disclosed
WO-2024027109-A1 CATALYST, PREPARATION METHOD THEREFOR AND USE THEREOF XIAMEN UNIVERSITY (CN) 2024-02-08 WO disclosed
WO-2021214315-A1 PURINE DERIVATIVES AS DRUGS FOR THE TREATMENT OF NEONATAL HYPOXIA-ISCHEMIA BRAIN INJURY AND RELATED DISEASES COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) 2021-10-28 WO disclosed
EP-3901154-A1 PURINE DERIVATIVES AS DRUGS FOR THE TREATMENT OF NEONATAL HYPOXIA-ISCHEMIA BRAIN INJURY AND RELATED DISEASES Commissariat à l'énergie atomique et aux énergies alternatives (FR) 2021-10-27 EP disclosed
WO-2011033225-A2 SUBSTITUTED 3-AMINO-CINNOLIN-4(1H)-ONE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2011-03-24 WO disclosed